tenocyclidine 

Action and Spectrum

Actions and spectrum: 

The main functions of the TCP are related to inhibitive actions on 3A-subunit of NMDAR, and acts as a non-competitive antagonist of NMDAR in Homo sapiens. The TCP molecule shows very high binding to the D1 subunit of the human DAT and it also causes an inhibitory effect on the α7-subunit of the Nicotinic Acetylcholine Receptor (nAChR). Additionally, it also takes over the μ-opioid receptor, which is the reason for the main effects of drugs from this class.  

Drug Interaction

Adverse Reaction

Adverse reactions 

Psychotic symptoms  

Severe Muscle contractions  

seizures  

Black Box Warning

Black box warning 

No specific black box warning is available  

Contraindication / Caution

Contraindications/Caution 

Hypersensitivity 

Allergy 

Psychiatric disorders 

Cardiovascular conditions 

Seizures  

Pregnancy / Lactation

Pregnancy & breastfeeding: 

Pregnancy consideration: 

US FDA pregnancy category: C 

Breastfeeding warnings: 

Data about the excretion of the drug into human milk is not known 

Pregnancy category: 

• Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester. 
• Category B: There was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women. 
• Category C: There was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women. 
• Category D: Adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits. 
• Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women. 
• Category N: No data for the drug under this category is available. 

Pharmacology

Pharmacology: 

Tenocyclidine is a derivative of phencyclidine. It is a dissociative anaesthetic compound containing hallucinogenic and stimulant effects. It was included under Schedule 1 in the year 1970 and is more potent than PCP. 

Pharmacodynamics: 

This drug shows more affinity towards NMDA receptors and less towards sigma receptors than phencyclidine does. 

Pharmacokinetics: 

Limited data available  

Adminstartion

Administration: 

As suggested by in vivo studies, it is administered intraperitoneally. This should be given by a qualified medical professional unlike dissociative anesthetics. 

Patient Information Leaflet

Patient information leaflet 

Generic Name: tenocyclidine 

Why do we use tenocyclidine? 

It is used as a psychostimulant drug. It is also employed as a hallucinogenic and neuroprotective agent. It is also applied as an NMDA receptor antagonist.