Microbial and Systemic Effects of SNAC-Enabled Oral Semaglutide Administration
February 20, 2026
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Brand Name :
N/A
Synonyms :
LJC 11036, tebipenem
Class :
Carbapenems, Beta lactam antibiotics
Brand Name :
N/A
Synonyms :
LJC 11036, tebipenem
Class :
Carbapenems, Beta lactam antibiotics
Currently awaiting FDA approval for the treatment of complex urinary tract infection (cUTI)
In the process of receiving FDA clearance for the treatment of acute pyelonephritis
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Actions and Spectrum:
Actions:
Tebipenem is highly active against class A (including ESBLs) and class C-lactamase-transformed germs, but not against class B (metallolactamase)-transformed pathogens.Tebipenem is effective against class A (including ESBLs) and class C-lactamase-transformed strains, but not against class B (metallolactamase)-transformed strains.
Spectrum:
Tebipenem is an oral carbapenem antibiotic that has broad-spectrum efficacy against Gram-positive and -negative bacteria except for Pseudomonas aeruginosa.
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Pregnancy consideration:
No data is available regarding the administration of the drug during pregnancy.
Breastfeeding warnings:
No data is available regarding the excretion of drug in breast milk.
Pregnancy category:
Category A: well-controlled and satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence these categories of drugs need to be avoided by pregnant women.
Category N: No data is available for the drug under this category.
Pharmacology:
Tebipenem, like other beta-lactam antibiotics, penetrates through the outer membrane into the periplasmic region. After acylation of tebipenem in the periplasmic region, penicillin-binding proteins (PBPs) are blocked. Thus, the production of cell wall peptidoglycan is catalyzed, weakening the peptidoglycan and resulting in bacterial cell lysis.
Pharmacodynamics: N/A
Pharmacokinetics: N/A
N/A
Patient information leaflet
Generic Name: tebipenem
Pronounced: teh-bee-pen-em
Why do we use tebipenem?
Tebipenem is frequently used to treat severe infections such as complicated urinary tract infections (cUTI), complicated intra-abdominal infections (cIAI), and other complex illnesses that require a strong antibiotic.
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