Microbial and Systemic Effects of SNAC-Enabled Oral Semaglutide Administration
February 20, 2026
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Brand Name :
N/A
Synonyms :
sabizabulin
Class :
SARS-CoV-2, Antivirals
Brand Name :
N/A
Synonyms :
sabizabulin
Class :
SARS-CoV-2, Antivirals
Dosage Forms & Strengths
Capsule
8mg
Administer 9mg daily once for 21 days
Dosage Forms & Strengths
N/A
Refer adult dosing
sabizabulin has a dual function, acting as both an anti-inflammatory and antiviral agent. Its mechanism involves disrupting microtubule filaments, which are integral to cellular structure and processes.
By binding to alpha and beta tubulin, it inhibits tubulin polymerization, impacting cell migration, cytokine release, and intracellular trafficking. This interference with microtubules plays a crucial role in hindering viral infection, including that of SARS-CoV-2, by disrupting processes essential for viral replication and spread.
Frequency defined
N/A
Black box warning:
None
Contraindications/caution:
Contraindications:
N/A
Caution:
N/A
Pregnancy consideration: N/A
Lactation: N/A
Pregnancy category:
Category A: well-controlled and Satisfactory studies show no risk to the fetus in the first or later trimester.
Category B: there was no evidence of risk to the fetus in animal studies, and there were not enough studies on pregnant women.
Category C: there was evidence of risk of adverse effects in animal reproduction studies, and no adequate evidence in human studies must take care of potential risks in pregnant women.
Category D: adequate data with sufficient evidence of human fetal risk from various platforms, but despite the potential risk, and used only in emergency cases for potential benefits.
Category X: Drugs listed in this category outweigh the risks over benefits. Hence, these categories of drugs need to be avoided by pregnant women.
Category N: There is no data available for the drug under this category
Pharmacology:
sabizabulin has a dual function, acting as both an anti-inflammatory and antiviral agent. Its mechanism involves disrupting microtubule filaments, which are integral to cellular structure and processes. By binding to alpha and beta tubulin, it inhibits tubulin polymerization, impacting cell migration, cytokine release, and intracellular trafficking. This interference with microtubules plays a crucial role in hindering viral infection, including that of SARS-CoV-2, by disrupting processes essential for viral replication and spread.
Pharmacokinetics:
N/A
Administration:
N/A
Patient information leaflet
Generic Name: sabizabulin
Why do we use sabizabulin?
sabizabulin is prescribed to hospitalised COVID-19 patients who are at high risk of developing acute respiratory distress syndrome (ARDS).
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